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THZ-1 hydrochloride
CAS No.
THZ-1 hydrochloride ( CDK7 inhibitor THZ1 )
Catalog No. M16941 CAS No.
THZ-1 hydrochloride is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM; also weakly inhibits CDK12 with IC50 of 250 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 108 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameTHZ-1 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionTHZ-1 hydrochloride is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM; also weakly inhibits CDK12 with IC50 of 250 nM.
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DescriptionTHZ-1 hydrochloride is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM; also weakly inhibits CDK12 with IC50 of 250 nM; displays broad-based activity a subset of cancer cell lines with IC50s of <200 nM; causes decreased cellular proliferation and an increase in apoptotic index (MCL-1, XIAP), disproportionally affects transcription of RUNX1 in Jurkat T-ALL cells; demonstrates efficacy against primary leukemia cells and in a bioluminescent xenografted model at 10mg/kg.
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SynonymsCDK7 inhibitor THZ1
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight602.51
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Molecular FormulaC31H29Cl2N7O2
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Purity>98% (HPLC)
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SolubilityDMSO: 22.5 mg/mL
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SMILES——
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Chemical NameBenzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-, Hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kwiatkowski N, et al. Nature. 2014 Jul 31;511(7511):616-20.
2. Chipumuro E, et al. Cell. 2014 Nov 20;159(5):1126-39.
3. Christensen CL, et al. Cancer Cell. 2014 Dec 8;26(6):909-22.
2. Chipumuro E, et al. Cell. 2014 Nov 20;159(5):1126-39.
3. Christensen CL, et al. Cancer Cell. 2014 Dec 8;26(6):909-22.
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